Abstract
ObjectiveThis study is to investigate the relationship between marital status and prognosis of patients with ovarian serous carcinoma.ResultsWe performed data analysis from 19,276 patients identified from the SEER database of the National Cancer Center of the United States. 57.8% of the patients were married, 13.0% unmarried, and 29.2% separated/ divorced/widowed (SDW). The median overall survival time ofthe unmarried group and the married group are 48 months and 52 months respectively. Univariate Cox regression analysis showed that the patients with serous ovarian cancer in the unmarried group resulted in a hazard ratio (HR) of 1.14 (95% CI: 1.08–1.19%; P < 0.001), comparing to SDW group with a HR of 1.02 (95% CI: 0.98–1.19%; P = 0.26). However, the SDW group was not statistically significantly different from the married group. (median 32 vs 52 months). Multivariate Cox regression analysis presented the unmarried group leading to a HR of 1.05 (95% CI: 1.00–1.11%; P = 0.05), and the SDW group was not significant with a HR of 0.99 (95% CI: 0.95–1.03%; P = 0.57).ConclusionUnmarried patients with ovarian serous carcinoma have higherHRof overall survival. After controlling age, race, grade, radiation and year of diagnosis, unmarried patients were found to have a significantly higher risk of OS. Consequently, these patients are suggested to obtain more focused healthcare for the management of ovarian serous carcinoma.
Highlights
Ovarian cancer is one of the most common malignant tumors in the female reproductive system
This study investigated the relationship between marital status and serous ovarian cancer prognosis by data analysis of the SEER database of the National Cancer Center of the United States
The data was analyzed by SEER*STAT 8.3.2, and ovarian cancer patients were filtrated from year 1973 to year 2013 by diagnosed date
Summary
Ovarian cancer is one of the most common malignant tumors in the female reproductive system. The incidence of ovarian cancer is lower than that of cervical cancer and uterine cancer, the mortality rate of ovarian cancer is the highest in gynecological malignancies [1,2,3]. Luo et al Journal of Ovarian Research (2019) 12:126 no literature reporting the impact of marital status on the prognosis of ovarian cancer. This study investigated the relationship between marital status and serous ovarian cancer prognosis by data analysis of the SEER database of the National Cancer Center of the United States. Analysis and survival curve was derived from KaplanMeier estimation. Multivariate Cox proportional hazard regression model was used to evaluate the mortality risk. All statistical tests were doublesided, and P ≤ 0.05 was considered as statistically significant
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