Abstract
Purpose/Objective: Two randomized trials of patients treated by breast conserving therapy have demonstrated a significant increase in local control, for patients with negative margins, when a tumor bed boost was used in addition to whole breast irradiation. However, in patients with positive or close margins, the adequacy of tumor bed boost for local control and the optimal boost dose remain controversial. Published reports have suggested that tumor bed boost, even at higher doses, is not sufficient to overcome the negative effect of close or focally positive margins. The purpose of this study is to assess the impact of boost dose on local recurrence rate according to margin status.
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