Influence of Magnetic Nanoparticles on the Focused Ultrasound Hyperthermia.

Katarzyna Kaczmarek,Arkadiusz Józefczak,Bernadeta Dobosz,Tomasz Hornowski

doi:10.3390/ma11091607

Katarzyna Kaczmarek, Arkadiusz Józefczak + Show 2 more

Open Access

https://doi.org/10.3390/ma11091607

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Journal: Materials	Publication Date: Sep 4, 2018
Citations: 26	License type: CC BY 4.0

Affiliation: Adam Mickiewicz University in Poznań

Abstract

Ultrasound hyperthermia is a medical treatment used to increase temperature of tissues. It can be used independently or as a supportive method for an anticancer treatment. The therapeutic efficacy of focused ultrasound hyperthermia can be improved using sonosensitizers, nanoparticles enhancing the attenuation and dissipation of acoustic energy. As sonosensitizers, we propose magnetic nanoparticles owing to their biodegradability, biocompatibility, and simple positioning in tissues using a magnetic field. Focused ultrasound hyperthermia studies were performed using tissue-mimicking phantoms. Temperature changes were measured at various ultrasound powers and distances from the center of the ultrasound focus. Specific absorption rate (SAR) values, describing the power deposition in the tissues during the hyperthermia treatment, were evaluated for the center of the focus point and for various distances from it. The results show that the addition of nanoparticles increases the SAR almost two times compared to that for the pure phantom. The highest SAR is obtained in the ultrasound focus; it decreases with the increase of the distance from the focus.

Highlights

The clinical ultrasounds are acoustic waves with frequencies in the range of 1–10 MHz
The aim of this study is to investigate the thermal effect of focused ultrasound (FUS) hyperthermia enhanced by magnetic nanoparticles as a function of the acoustic power and distance from the center of the ultrasound focal zone
Magnetic nanoparticles were used as sonosensitizers, synthetized at the Institute

Summary

Introduction

The clinical ultrasounds are acoustic waves with frequencies in the range of 1–10 MHz. Ultrasounds are used in diagnostic medical imaging, referred to as ultrasonography and ultrasound tomography [3,4,5,6,7]. They are very important in enhanced drug uptake through skin, i.e., sonophoresis, transdermal drug delivery, and lithotripsy to destroy kidney stones [2,3]. They have been employed in various thermal therapies. Depending on the temperature increase induced by the ultrasound waves, a few thermal therapies can be distinguished [2,8]

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