Abstract
The effect of magnetic nanoparticles coated with arabinogalactan on the viability of Ehrlich ascites carcinoma (EAC) cells was studied. The nanoparticles were studied by transmission electron microscopy, Mössbauer spectroscopy, IR spectroscopy, and ferromagnetic resonance. A correlation between the proportion of dead EAC cells in suspension and the intensity of the EPR signal of dinitrosyl iron complexes was found. This result may be due to the presence of NO molecules.
Highlights
INTRODUCTIONNanoparticles (including non-magnetic) are attracting special attention for use in tumor immunotherapy
Nanoparticles are attracting special attention for use in tumor immunotherapy
Nanoparticles can affect the phagocytic activity of macrophages, the yield of nitric oxide (NO) and reactive oxygen species
Summary
Nanoparticles (including non-magnetic) are attracting special attention for use in tumor immunotherapy. The authors of Ref. 4 have demonstrated that magnetite nanoparticles are more effective than hematite nanoparticles in polarizing macrophages and suppressing tumors. Among the magnetic nanoparticles involved in the metabolism of living organisms, ferrihydrite with the nominal formula Fe2O3⋅nH2O plays a special role. It is formed in the nucleus of the ferritin protein complex, which is a capsule of the protein apoferritin and serves as the storage of iron in the body. This work aims to synthesize and study the magnetic properties of ferrihydrite nanoparticles coated with the natural polysaccharide arabinogalactan, as well as to study the possible effect of ferrihydrite nanoparticles on the suppression of Ehrlich ascites carcinoma (EAC) tumor
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