Abstract
The cytosolic free Ca 2+ concentration [Ca 2+]i and dense tubular system (DTS) of washed human platelets were affected by low density lipoproteins (LDL) of 25 μg/ml at 37 0 C for 10 minutes. After the incubation with LDL, the [Ca 2+]i increased from 115±29 nM to 141±24 nM. LDL promoted the increase of [Ca 2+]i (471±31 nM) induced by thrombin (0.03 U/ml) as compared to that which thrombin did alone (240±11 nM) ( p<0.05). The increased Ca 2+ influx from the extracellular space is thought to be the reason of the increase in [Ca 2+]i, since the effect of LDL was abolished by removal of external Ca 2+ by EGTA. The DTS changed primarily from thin elongated forms to rounded vesicles. No evidence was noticed that LDL caused a mobilization of Ca 2+ from the DTS.
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