Abstract
The present study described the fabrication and characterization of puerarin-loaded lipid nanoparticles with blends of glyceryl monostearate (solid lipid phase) and DELIOS® MCT (liquid lipid phase) as the lipid matrices. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared via controlling the ratio of liquid lipid to solid lipid. The drug–lipid compatibility was evaluated via theoretical calculation of solubility parameters and X-ray diffraction analysis. The influence of liquid lipid content on the particle size, morphology, stability, drug loading properties of the lipid nanoparticles and in vitro release behavior of puerarin was investigated. Both SLN and NLC exhibited good stability and spherical shapes, and no significant difference in particle size occurred for the NLC series. The drug loading capacity and entrapment efficiency of the lipid nanoparticles were affected with increasing the liquid lipid content, and the presence of liquid lipid had a positive effect on ...
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