Abstract
In the present study the influence of liposomal formulations on the in vitro absorption of methyl nicotinate (MN) taken as model drug was investigated. Special attention was paid to the possible correlations between the characteristics of the liposome formulation and its `in vitro' performance. The preparation of a set of MN-containing liposomal formulations is described; these differ in soybean phosphatidylcholine (PC) concentration, lipid charge (by using either cationic or anionic surfactants), vesicle size and viscosity. Liposomes were prepared as aqueous suspensions, or as viscous gels using the acrylic polymer carbomer. The in vitro determination of MN permeability when released from the different liposomal formulations was performed using a Franz cell assembled with a synthetic silastic/cellulose/silastic multimembrane system. The results indicated that MN permeability was directly related to PC concentration and inversely related to liposome size and to vehicle viscosity; the liposome charge only slightly influenced the in vitro absorption of MN.
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