Abstract
The aim of this work was to study the release kinetics of a water-soluble drug from two different W/O/W multiple emulsions prepared with two lipophilic surfactants at different concentrations. The study of the kinetics under both iso-osmotic and hypo-osmotic conditions allowed us to distinguish between two possible release mechanisms: swelling-breakdown or facilitated diffusion. The results obtained indicate that water-soluble drug release occurs by a mechanism of swelling followed by a breakdown of the oil globules, in which the lipophilic surfactant is a decisive factor. It appears that the globule's swelling capacity is considerably increased when the lipophilic surfactant concentration increases, and the more the oil globule swells, the less the water-soluble drug releases. It seems that the stability could be improved by increasing the lipophilic surfactant concentration which could strengthen the interfacial film. In contrast, an excess of hydrophilic surfactant destabilized the emulsion.
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