Abstract
The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions. Twenty-six patients (9 males and 17 females) were treated with multiple extractions (2 to 8), with a total of 108 extractions. This was an exploratory single blinded randomized clinical trial with a split-mouth design. The pain after the surgery was assessed in each patient by the VAS scale (1 to 10) at intervals of 24-48-72-96 hours. The soft tissue healing was clinically evaluated at 3, 7, 14, and 21 days after surgery by the same examiner surgeon, using the modified Healing Index (4 to 12). The mean value of postextraction pain was 3.2 ± 0.3 in the experimental sides and 4.1 ± 0.1 in the control sides. After 7 days from the extractions, the values of modified Healing Index in the experimental and control groups were, respectively, 4.8 ± 0.6 and 5.1 ± 0.9. The use of L-PRF in postextraction sockets filling can be proposed as a useful procedure in order to manage the postoperative pain and to promote the soft tissue healing process, reducing the early adverse effects of the inflammation.
Highlights
Many studies revealed that platelet concentrates for surgical use can be used as efficient adjuvants for tissue repair [1,2,3,4,5]
The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions
Platelet concentrates are classified into 4 main families depending on their leukocyte and fibrin content: pure platelet-rich plasma (P-PRP), leukocyte- and platelet-rich plasma (L-PRP), pure platelet-rich fibrin (PPRF), and leukocyte- and platelet-rich fibrin (L-PRF) [11]
Summary
Many studies revealed that platelet concentrates for surgical use can be used as efficient adjuvants for tissue repair [1,2,3,4,5]. The PRPs were already tested in many oral surgery applications, with mixed results depending on the kind of preparations [13,14,15,16]. Several authors demonstrated the effectiveness of some PRP types during tooth extractions to stimulate soft tissue healing and wound control [19, 20] and in prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery. These PRP techniques remain quite complex and expensive on a daily use basis, and their use may not be justified for daily oral surgery applications [13, 14]
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