Abstract
AIMTo identify if laser photocoagulation induces morphological changes specifically related to the choroidal capillary endothelial processes that protrude into Bruch's membrane.METHODSTwo human eyes and one adult macaque monkey eye received...
Highlights
Aim—To identify if laser photocoagulation induces morphological changes related to the choroidal capillary endothelial processes that protrude into Bruch’s membrane
The processes were longer 9 days after photocoagulation in the monkey, when compared with untreated monkeys, and some breached the elastic lamina, a phenomenon not seen in the untreated eyes
We have presented evidence that the cytoplasmic processes from the choroidal capillary endothelial cells increased in number and size in the human eye that was photocoagulated 5 days before exenteration
Summary
Three female patients (patient 1, 58 years old; patient 2, 45 years old; patient 3, 61 years old) undergoing exenteration as part of their treatment for meibomian gland carcinoma, consented to donate their normal globes to research. The eyes that had been photocoagulated had segments taken from the superior macula, at least 4 mm from any laser burn, to compare with specimens taken from the inferior macula that incorporated the laser lesions. Sections of the maculas were obtained from the central macula in eyes that were not treated and from areas equidistant from the horizontal raphe in the superior and inferior macula in eyes with laser burns. Those specimens taken from the treated half always included a visible laser lesion
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