Abstract
In order to study the influence of amino acid neurotransmitters secreted by the nerve cells after ketamine treatment, the nerve cells were cultured in vitro to exclude the interference of other factors in vivo and treated with three different doses of ketamine (1, 3 and 5 µg/mL). Then, the concentration of neuronal amino acid neurotransmitters was examined at 0, 15, 30, 45, 60, 90, 120 min after treatment. The trends of each amino acid concentration after ketamine treatment were nearly the same among the different treatment doses. After 15 min of adapting time, ketamine decreased the excitatory amino acid glutamic acid and aspartic acid concentration, and increased the concentration of the inhibitory amino acid glycine. Their concentrations showed a tendency to return approximately to the original level after 120 min.
Highlights
Ketamine, an n-methyl-D-aspartate antagonist, is commonly used for its sedative and analgesic properties in many species (Green et al, 1981)
Ketamine at 1, 3 and 5 μg/mL induced an increase of the aspartate concentration at 15 min, followed by a decrease, and an increase to reach the original concentration at 120 min
Ketamine at 1 μg/mL induced a 39% significant increase in aspartate concentration at 10 min (p
Summary
An n-methyl-D-aspartate antagonist, is commonly used for its sedative and analgesic properties in many species (Green et al, 1981). It could be administrated intramuscularly, intraperitoneally, or intravenously to provide relief of pain and distress (Song et al, 2012). In addition to its analgesic and anesthetic properties, ketamine possesses many advantages including easy administration, wide margin of safety, and its ability to be combined with other drugs (Gaertner et al, 2008). It is often used in combination with xylazine to anesthetize rodents. As a non-competitive antagonist, ketamine blocks NMDA receptor and induces a dissociative anesthesia (Bergman, 1999)
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