Abstract
T lymphocytes, cytokines, and macrophages play important roles in the clearance of Mycobacterium tuberculosis (Mtb) by the immune system. This study aimed to investigate the effects of isoniazid on the functions of both innate and adaptive immune cells. Healthy rats were randomly divided into experimental and control groups. Each group was randomly divided into three subgroups and named according to the duration of drug feeding, 1, 3, and 3 months followed by drug withdrawal for 1 month. The experimental groups were fed with isoniazid (12 mg/mL) and the control groups with normal saline. The percentage of CD4+ and CD8+ T lymphocytes, level of interleukin (IL)-12 and interferon (IFN)-γ, and function of macrophages were determined at these three time points. Isoniazid significantly increased the percentage of CD4+ T lymphocytes and the CD4+/CD8+ T lymphocyte cell ratio (P < 0.05). It transiently (<1 month) enhanced the functions of rat macrophages significantly (P < 0.05). In summary, isoniazid could increase the percentage of CD4+ T lymphocytes, CD4+/CD8+ T lymphocyte cell ratio, and enhance macrophage function in healthy rats.
Highlights
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) bacteria which may damage multiple organ systems and poses a serious harm to human health
Most people infected with Mtb develop a latent TB infection without any clinical symptoms that is not cleared by the immune system
When various factors cause a decrease in the body’s immune function, the latent Mtb can be activated, allowing it to develop into active TB (Petruccioli et al, 2016; Riou et al, 2016)
Summary
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) bacteria which may damage multiple organ systems and poses a serious harm to human health. According to the World Health Organization’s report on the global tuberculosis epidemic, about one-third of the world’s population was infected with Mtb in 2015, 10.4 million new TB patients were diagnosed, and more than 1.4 million patients died of the disease (Sisay et al, 2016). T lymphocytes, cytokines, and macrophages play important roles in the clearance of Mtb-related antigens. It has been found that some antibacterial drugs kill pathogens and regulate immune function during treatment (Hamilton-Miller, 2001; Schultz, Speelman, van der Poll, 2001; Tauber, Nau, 2008). Anti-tuberculosis drugs have been used for many years, studies on
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
