Abstract
SynopsisThe intrinsic effects of ionizing radiation on molecular recognition between an antibiotic and its re-ceptor have been probed by coupling a synchrotron beamline to a tandem mass spectrometer. Protonated vanco-mycin-receptor non-covalent complexes in the gas phase undergo inter-as well as intramolecular bond cleavage due to internal energy transfer after photoabsorption in the VUV-X energy range. The deprotonated complex undergoes electron detachment, but the native interactions underlying molecular recognition are not systematically lost.
Highlights
M Abdelmouleh, M Lalande, A Espinosa Rodriguez, V Vizcaino, J Rangama, et al
Synopsis The intrinsic effects of ionizing radiation on molecular recognition between an antibiotic and its receptor have been probed by coupling a synchrotron beamline to a tandem mass spectrometer
We have studied photoionization of isolated protonated as well as deprotonated vancomycin/receptor complexes by means of a synchrotron beamline coupled to a tandem mass spectrometer, which allowed identifying the irradiation products
Summary
M Abdelmouleh, M Lalande, A Espinosa Rodriguez, V Vizcaino, J Rangama, et al. Influence of ionizing radiation on molecular recognition in the gas phase: VUV and X-ray photoabsorption of antibiotic-receptor non-covalent complexes. 31st International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC XXXI) 23-30 July 2019, Deauville, France, 2020, Deauville, France. pp.152061, 10.1088/1742-6596/1412/15/152061. hal-03349486. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
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