Influence of intrinsic sympathomimetic activity of beta-adrenoceptor blockers on the heart rate and blood pressure responses to graded exercise.

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British Journal of Clinical PharmacologyVolume 12, Issue 3 p. 355-362 Free Access Influence of intrinsic sympathomimetic activity of beta-adrenoceptor blockers on the heart rate and blood pressure responses to graded exercise. G Jennings, G JenningsSearch for more papers by this authorA Bobik, A BobikSearch for more papers by this authorP Korner, P KornerSearch for more papers by this author G Jennings, G JenningsSearch for more papers by this authorA Bobik, A BobikSearch for more papers by this authorP Korner, P KornerSearch for more papers by this author First published: September 1981 https://doi.org/10.1111/j.1365-2125.1981.tb01226.xCitations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat REFERENCE ABLAD, B., BORG, D.O., CARLSSON, E., EK, L., JOHNSSON, G., MALMFORS, T. & REGARDH, C. (1975). A survey of the pharmacological properties of metoprolol in animals and man. Acta Pharmac. Tox., 36 suppl V, 7– 23. BAILEY, I.K., ANDERSON, S.D., ROZEA, P.J., BERNSTEIN, L., NYBERG, G. & KORNER, P.I. (1976). Effect of beta adrenergic blockade with alprenolol on ST-segment depression and circulatory dynamics during exercise in patients with effort angina. Am. Heart. J., 93, 416– 426. BANGAH, M., JACKMAN, G. & BOBIK, A. (1980). Determination of pindolol in human plasma by high performance liquid chromatography. J. Chromatog., 183, 255– 259. BOBIK, A., JENNINGS, G.L., ASHLEY, P. & KORNER, P.I. (1979). Timolol pharmacokinetics and effects on heart rate and blood pressure after acute and chronic administration. Eur. J. clin. Pharmac., 16, 243– 249. BOBIK, A., JENNINGS, G.L., ASHLEY, P. & KORNER, P.I. (1981). Relationship between timolol plasma concentration and its duration of action. Studies in normotensive and hypertensive subjects. In Proceedings of the Intercontinental Symposium Timolol, Rahway, Merck & Co. Inc: (in press). BOBIK, A., JENNINGS, G.L., KORNER, P.L., ASHLEY, P. & JACKMAN, G. (1979). Absorption and excretion of rapid and slow release oxprenolol and their effects on heart rate and blood pressure during exercise. Br. J. clin Pharmac., 7, 545– 549. BURKE, T.R. & NELSON, W.L. (1979). Synthesis of 4′ and 5′ hydroxyoxprenolol: Pharmacologically active ring hydroxylated metabolites of oxprenolol. J. med. Chem., 22, 1535– 1537. GARTIEZ, D. (1971). Metabolism of a β-blocking drug, oxprenolol. J. Pharmac. exp. Ther., 179, 354– 358. JENNINGS, G.L., BOBIK, A., FAGAN, E.T. & KORNER, P.I. (1979). Pindolol pharmacokinetics in relation to time course of inhibition of exercise tachycardia. Br. J. clin. Pharmac., 7, 245– 256. JENNINGS, G.L., BOBIK, A. & KORNER, P.I. (1979). Comparison of effectiveness of timolol administered once a day and twice a day in the control of blood pressure in essential hypertension. Med. J. Aust., 2, 263– 265. JOHNSSON; G., REGARDH, G. & SOLVELL, O. (1975). Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic ft antagonist metoprolol. Acta Pharmac. Tox., 36, suppl V: 31– 44. KENAKIN, T.P. & BLACK, J.W. (1978). The pharmacological classification of practolol and chlorpractolol. Mol. Pharmac., 14, 607– 623. McDEVITT, D.G., BROWN, C.H., CARRUTHERS, S.G. & SHANKS, R.G. (1976). Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade. Clin. Pharmac. Ther., 21, 556– 565. PARKER, P.B. & WAUD, D.R. (1971). Pharmacological estimation of drug-receptor dissociation constants. Statistical Evaluation I Agonists. J. Pharmac. exp. Ther., 117, 1– 12. SNEDECOR, G.W. & COCHRAN, W.G. (1967). Statistical Methods, 6th Edition, 259– 295, 419–446. Ames: Iowa State University Press. TOCCO, D.J., DUNCAN, A.E.W., DeLUNA, F.A., HUEKER, M.B., GRUBER, V.F. & VANDENHAUVEL, W.J.A. (1975). Physiological disposition and metabolism of timolol in man and laboratory animals. Drug Metab. Dispos., 3, 316– 370. WAAL-MANNING, E. (1976). Hypertension: Which beta blocker Drugs, 12, 412– 441. WAGNER, J.G. (1968). Kinetics of pharmacological response. I. Proposed relationship between response and drug concentration in the intact animal and man. J. theor. Biol, 20, 173– 201. Citing Literature Volume12, Issue3September 1981Pages 355-362 ReferencesRelatedInformation