Abstract
The validity of the hypothesis that aromatization of androgens in the hypothalamus is a prerequisite for induction of sterilization in female rats androgenized neonatally was tested by implanting paraffin micropellets containing 16β-ethylestradiol-17β (EED) or l,4,6-androstatriene-3,17-dione (ATD), directly into the hypothalamus of neonatal female rats 6 h prior to a single subcutaneous injection of testosterone propionate (TP). The antagonists did not impair the sterilizing action of TP but enhanced the induction of sterility. By contrast, intrahypothalamic implantation of paraffin micropellets containing 1% TP together with 50% MER-25, an antioestrogen, brought about a significant suppression of induction of sterility. The reasons why intrahypothalamic implants of antioestrogen or aromatase inhibitor failed to suppress the sterilizing effect of TP subcutaneously injected were discussed.
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