Influence of intestinal barrier in severe multiple trauma patients by the early treatment of rhubarb and microecopharmaceutics-supplemented enteral nutrition

Abstract

Objective To study the influence of intestinal barrier in severe multiple trauma patients by the early treatment of rhubarb and microecopharmaceutics-supplemented enteral nutrition. Methods Eighty-two multiple trauma patients [injury severity score(ISS)> 20] were selected. Eighty-two patients in severe multiple trauma who were assigned randomly to combined treatment group or control group.The patients in control group were treated with classical therapy, those in combined treatment group were infused with the rhubarb and microecopharmaceutics-supplemented enteral nutrition. Blood samples were collected 1 and 8 day after trauma for plasma levels of D-lactate, and the plasma contents of TNF-α, IL-6 were determined. Meanwhile, the mortality of sepsis and multiple organ dysfunction syndrome(MODS), the morbidity of detection within 28 days. Results Results were found in those were early treated with patients in the combined treatment, 8 days after trauma for plasma levels of D-lactate, TNF-α, IL-6 were determined increased significantly than that in control group(P<0.05); Within 28 days mortality of sepsis in 12 patients (29.26%) (P<0.01), MODS in 11 patients (26.83%) (P<0 01) and the morbidity in 5 patients (12.2%) (P<0.05), the combined treatment group increased significantly than that in control group. Conclusions Rhubarb and microecopharmaceutics-supplemented enteral nutrition can improve the intestinal barrier, and effectively prevent bacterial translocation and endotoxemia through its intestinal barrier, improve gut barrier function and the prognosis. Key words: Multiple trauma; Intestinal barrier; Rhubarb; Microecopharmaceutics; Sepsis