Abstract
Objective: The aim of this review is to summarize the effects of local and systemic PTH administration on periodontal tissues during orthodontic tooth movement. Materials and methods: An electronic search was conducted on the following databases: PubMed/MEDLINE, Google Scholar, SCOPUS and Embase. On PubMed/MEDLINE, the Medical Subject Headings (MeSH) keywords used were: “orthodontic tooth movement” OR (“tooth” (All Fields) AND “tooth movement” (All Fields)) OR “tooth movement” (All Fields)) AND (“parathyroid hormone”); all studies included using CONSORT. Results: After elimination of duplicates and articles not meeting our inclusion criteria, seven animal studies were included in this review. Although the majority of the studies suggest that PTH may a have a favorable outcome on OTM, most studies were found to have several sources of bias. Conclusion: Animal studies with minimal bias and long-term clinical studies are needed to ascertain the efficacy of intermittent PTH administration in improving the rate and retention of OTM.
Highlights
Orthodontic treatment involves the movement of teeth by application of forces via removal and fixed appliances [1]
A number of factors can affect the rate of Orthodontic tooth movement (OTM). These include systemic disease such as diabetes [4], osteoporosis [5] and other metabolic disorders. Drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and bisphosphonates [6] have been observed to affect the rate of OTM
Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Participants, Intervention, Control and Outcomes statement (PICO) [17], the following focused question was formulated: “What is the effect of local and systemic parathyroid hormone on outcomes of orthodontic tooth movement when compared to orthodontic force alone?”
Summary
Orthodontic treatment involves the movement of teeth by application of forces via removal and fixed appliances [1]. A number of factors can affect the rate of OTM These include systemic disease such as diabetes [4], osteoporosis [5] and other metabolic disorders. Drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and bisphosphonates [6] have been observed to affect the rate of OTM. Oral diseases such as periodontitis adversely affect the outcome of orthodontic treatment [7]. To improve the rate of OTM and reduce the probability of orthodontic relapse, a number of methods have been proposed These include surgery, transeptal fiberectomy and low-level laser therapy [8,9].
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