Abstract
Background Th2 cells are the central mediators of the allergic immune response, as their activation induces it by cytokine release. The key cytokines expressed by Th2 cells and involved in the pathogenesis of allergic airway inflammation and immunoglobulin E (IgE) production are interleukin-4 (IL-4), IL-5, IL-10 and IL-13. The aim of study was to evaluate the in vitro effect of Der p 1, the major allergen of Dermatophagoides pteronyssinus (house dust mite, HDM), on IL-4 and IL-13 production by naive CD4+ T cells cocultured with dendritic cells (DCs) from HDM allergic patients, as well as their influence on serum IgE levels.
Highlights
Th2 cells are the central mediators of the allergic immune response, as their activation induces it by cytokine release
The key cytokines expressed by Th2 cells and involved in the pathogenesis of allergic airway inflammation and immunoglobulin E (IgE) production are interleukin-4 (IL-4), IL-5, IL-10 and IL-13
The aim of study was to evaluate the in vitro effect of Der p 1, the major allergen of Dermatophagoides pteronyssinus, on IL-4 and IL-13 production by naive CD4+ T cells cocultured with dendritic cells (DCs) from HDM allergic patients, as well as their influence on serum IgE levels
Summary
Th2 cells are the central mediators of the allergic immune response, as their activation induces it by cytokine release. Influence of Interleukin-4 and Interleukin-13 on serum immunoglobulin E in house dust mite allergy Background Th2 cells are the central mediators of the allergic immune response, as their activation induces it by cytokine release. The key cytokines expressed by Th2 cells and involved in the pathogenesis of allergic airway inflammation and immunoglobulin E (IgE) production are interleukin-4 (IL-4), IL-5, IL-10 and IL-13.
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