Abstract
The effect of influenza and Sendai viruses on the rotational mobility of band 3 proteins in the human erythrocyte membrane was measured using the technique of flash photolysis. Both viruses produced a marked reduction of band 3 rotation. In the case of Sendai virus, loss of mobility correlated with aggregation of intramembrane particles seen in freeze-fracture electron microscopy following fusion of viral envelopes with the plasma membrane. No such aggregation is seen with influenza virus and it is concluded that immobilization is associated with cross-linking of the virus receptor, glycophorin A, by the adsorbed virus particle. This result is consistent with the existence of a structural association between glycophorin A and band 3.
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