Influence of increasing 2′- O-methylation on the interferon stimulating capacity of poly(rI) · poly(rC)

Abstract

A set of 2′- O-methylated derivatives of poly(rI) · poly(rC) have been prepared and studied for interferon inducing and antiviral activities. Introduction of 2′- O-methyl groups in the polycytidylic strand of this duplex impairs the interferon stimulation capacity more than similar modification of the polyinosinic strand.