Abstract
During the course of an investigation by one of us1 of the effect of vagal stimulation on the production of gastric secretion, it was observed that artificial ventilation considerably diminished the volume of the secretion. To ascertain the factors involved in this effect the following experiments were performed on dogs anesthetized with a chloralose and urethane mixture given intravenously.1. Gastric secretion was obtained by vagal stimulation in the neck. The right and left nerves were stimulated alternately for 10 minutes each throughout the experiment. 2. Hyperventilation was applied. 3. Hyperventilation was continued at the same rate using an artificial air-carbon-dioxide mixture.A study was made of the gastric juice, the collecting tubes being changed every 10 minutes. Total and free acid were determined by titration, and total chlorides by the method of Wilson and Ball.2 The arterial (carotid) plasma carbon dioxide content was determined by the volumetric method of Van Slyke, and the plasma pH by t...
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