Abstract
The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied. Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated. Lower BIC was observed in DR (35.35±18.04) compared with the HR (69.07±09.01) (p=0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p=0.03; HBOT after implantation was p=0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p≥0.21). HBOT, either before or after implantation, increased the BIC in DR to the level of HR.
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