Abstract
Objective To observe the effect of hyperbaric oxygen (HBO) therapy on bone ingrowth into porous implant in a rabbit model of avascular necrosis of femoral head induced by dexamethasone. Methods Thirty-two New Zealand rabbits were subject to intramuscular injection of dexamethasone twice a week for 8 weeks.Then,rabbits were divided into 4 groups:control group,HBO group,recombinant human bone morphogenetie protein-2 (rhBMP-2) group and HBO + rhBMP-2 group randomly.The femurs of rabbits in control group and HBO group were implanted with bare porous implants,while the rhBMP-2 group and HBO + rhBMP-2 group were implanted with porous implants of collagen compounded with rhBMP-2.Control group and rhBMP-2 group were treated without HBO;HBO group and HBO + rhBMP-2 group were treated with HBO.All rabbits were sacrificed at the 12th weeks after operation.All samples of right femurs were used for making hard tissue slices,while all samples of left femurs were used for biomechanics test. Results The oaseointegration rate:HBO + rhBMP-2 group ＞ HBO group ＞ rhBMP-2 group ＞ control group.The difference between control group and rhBMP-2 group was not statistically significant (P＞0.05).Differences among all other groups were statistically significant (P＜0.05).New bone ingrowth rate:HBO group ＞ HBO + rhBMP-2 group ＞ control group ＞ rhBMP-2 group.Differences between every two groups were statistically significant (P＜0.05).The results of pull out test showed that anti-shearing force in HBO group and HBO + rhBMP-2 group were greater than that in control group and rhBMP-2 group,the differences were statistically significant (P ＜0.05).Anti-shearing force in HBO + rhBMP-2 group was a little greater than that in HBO group,but there was no significant difference between the two groups (P ＞ 0.05).Anti-shearing force in rhBMP-2 group was significantly greater than that in control group (P＜0.05). Conclusions HBO therapy can improve osseointegration rate of bone and implant,promote new bone ingrowth into the porous implant,enhance the integration strength of bone and implant.HBO and rhBMP-2 have cooperative effect,but the carrier of rhBMP-2 can prevent bone ingrowth into implant. Key words: Hyperbaric oxygen; Hormone; Necrosis of femoral head; Porous implant; Osseointegration
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