Abstract
Background: Over 200 human telomerase reverse transcriptase (hTERT) polymorphism combinations have been implicated in the development of cancer. This study aimed to evaluate hTERT mutations in meningioma tissue and its association with meningioma.Material and Methods: A total of 90 patients who underwent surgery between 2006 and 2015 and were histopathologically diagnosed with meningioma (WHO 2016) were included.Results: Among the 90 participants included herein, 50 (55.5%) and 40 (44.5%) were female and male, respectively, with an average age of 56.2 ± 14 years. Mean Ki-67 values were 10.56% (SD 12.41, range 0-60), while the mean follow-up duration was 39.1 months (SD 26.3). Low- and high-grade patients had a mean Ki-67 score of 4.31% (SD 3.58, range 0-16) and 19.92% (SD 14.91, range 2-60) (p = 0.0001). Our results showed a moderate positive correlation between Ki-67 score and the presence of hTERT mutation (Pearson correlation test, r = 0.5161; p = 0.0001). Patients with an hTERT mutation > 30% had significantly higher risk for reoperation than those with lower levels of mutation (p = 0.016, chi square test). None of the patients requiring reoperation had an hTERT mutation < 10%. Moreover, high-grade patients had a 7.2 times higher risk of reoperation than those with an hTERT mutation > 30%.Conclusion: The presence of hTERT mutation, in addition to high Ki-67, indicated a more aggressive meningioma disease course and potentially increased risk of recurrence.
Highlights
Meningiomas, one of the common central nervous system (CNS) tumors that account for 30% of all intracranial tumors, originate from arachnoidal cap cells along the dura mater, generally progress slowly, and are mostly benign [1]
Patients with an human telomerase reverse transcriptase (hTERT) mutation < 10% had an average Ki-67 score of 4.13% (SD 3.42, range 0-12), whereas those with an hTERT mutation > 10% had an average score of 17.27% (SD 14.71, range 2-60) (p = 0.0001, t-test)
Among the LG group, patients with an hTERT mutation < 10% had a mean Ki-67 score of 3.54% (SD 2.99, range 0-12), whereas those with an hTERT mutation > 10% had an average score of 6.77% (SD 4.28, range 2-16) (p = 0.008, Mann-Whitney U test)
Summary
Meningiomas, one of the common central nervous system (CNS) tumors that account for 30% of all intracranial tumors, originate from arachnoidal cap cells along the dura mater, generally progress slowly, and are mostly benign [1]. These tumors have been classified into three groups by the World Health Organization (WHO). WHO grade I, II, and III tumors have a recurrence risk of 7%-25%, 29%-59%, and 60%-94%, respectively [3] Both histopathological grading and cytological evaluations are important. This study aimed to evaluate hTERT mutations in meningioma tissue and its association with meningioma
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