Abstract
ABSTRACT Objectives: to describe and analyze the influence of human rotavirus vaccine on hospitalizations for gastroenteritis in children under 5 years of age, in Brazil, 2001 to 2018 (pre- and post-vaccination period). Method: this is a retrospective, descriptive ecological study, combining the description of a time series from 2001 to 2018 and collected in the months August 2019 to Janaury 2020. The data were obtained from a secondary source. To analyze the effect of different variables, multiple models of mathematical evaluations were used (accumulated growth rate, geometric growth rate; standard deviation, mean, variance and simple linear regression). The level of significance was set at 5% (p <0.05). Results: there was a reduction in hospitalizations related to gastroenteritis in children under 5 years old, when comparing the pre- and post-vaccination periods. This reduction occurred in all Brazilian regions. Conclusion: after the implementation of human rotavirus vaccine, there was a significant reduction in hospitalizations of children under 5 years.
Highlights
Rotavirus belongs to the Reoviridae family, has a double strand of ribonucleic acid (RNA), can be transmitted via fecal-oral and through aerial propagation, and is often found in the feces of sick children[1]
The virus has seven groups (A to G), with only groups A, B and C being related to rotavirus infections in humans, and group A is responsible for 95% of the incidence in children
There was a growth trend in the Northeast, Southeast, South and CenterWest regions, only in the North there was a reduction in the growth rate
Summary
The virus has seven groups (A to G), with only groups A, B and C being related to rotavirus infections in humans, and group A is responsible for 95% of the incidence in children. It is known that the first rotavirus infection induces partial immunity against other serotypes, decreasing the symptoms of subsequent infections. Rotavirus is known to be one of the most relevant viral agents among diseases considered to be diarrheal[3]. The most common cause of diarrhea in children under five years of age worldwide, is caused by rotavirus, being responsible for approximately 600 thousand deaths per year and 40% of hospitalizations. In the American continent alone, there are an estimated 75,000 hospitalizations and 15,000 deaths annually. Rotavirus is considered ubiquitous and globally infects almost all children aged 3 to 5 years[4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
