Abstract
AbstractThe growth of estrogen receptor-positive and -negative human melanoma cells was compared in male and female athymic mice. The growth of all receptor-negative and receptor-positive tumors carried in male mice was significantly greater than receptor-positive tumors in female mice. The receptor-positive tumor growth rate in male mice was inhibited by exogenous estradiol while receptor-negative tumors were not. The results suggest that the favorable influence of sex on the natural history of human melanoma may be restricted to hormonally responsive lesions.
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