Abstract
MOST of the anti-histaminic drugs are local anæsthetics1. Procaine, too, has an anti-histaminic action2. Euler has demonstrated the presence of large amounts of histamine in certain nerves3. We have investigated the influence of histamine on the nerve block caused by procaine and some of the anti-histaminics. In the frog nerve–muscle preparation, we have found that a nerve block caused by, for example, pyribenzamine can be removed by washing with a solution containing, besides the blocking concentration of the local anæsthetic, a certain concentration of histamine. If the nerve is placed in contact with the mixture of histamine and blocking agent solution, no block results even when the concentration of the blocking agent is quite sufficient for producing block if applied alone. Two typical experiments follow.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.