Abstract
MOST of the anti-histaminic drugs are local anæsthetics1. Procaine, too, has an anti-histaminic action2. Euler has demonstrated the presence of large amounts of histamine in certain nerves3. We have investigated the influence of histamine on the nerve block caused by procaine and some of the anti-histaminics. In the frog nerve–muscle preparation, we have found that a nerve block caused by, for example, pyribenzamine can be removed by washing with a solution containing, besides the blocking concentration of the local anæsthetic, a certain concentration of histamine. If the nerve is placed in contact with the mixture of histamine and blocking agent solution, no block results even when the concentration of the blocking agent is quite sufficient for producing block if applied alone. Two typical experiments follow.
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