Abstract
Persons with multiple sclerosis (pwMS) report lower health-related quality of life (HRQoL) as compared to general and other chronic disease populations. High-intensity interval training (HIIT) has been shown to improve certain physical and cognitive measures more effectively than moderate training in pwMS. PURPOSE: To determine the influence of HIIT vs. moderate training over three weeks on HRQoL and motor/processing performance of activities of daily living (ADL) in pwMS with light-to-moderate disability status. METHODS: The intervention group (INT; n=36) cycled at 95-100% of HRmax during 5×1.5-min high-intensity intervals, whereas the control group (CON; n=36) cycled for 24 minutes at 65% of HRmax. Performance of ADL was quantified by the Assessment of Motor and Processing Skills. Physical and mental HRQoL were assessed using the Patient-Reported Outcome Measurement Information System short form Global-10. Between-subject and within-subject effects (baseline vs. post intervention) were analyzed by ANCOVA (Bonferroni corrected). Baseline measures were used as covariates. RESULTS: Results are presented as MEAN baseline ± MEAN change at post. No significant group interaction for either outcome measure was observed. Physical HRQoL improved significantly in both groups (INT: 12.662+1.256 [SE=.290], p<.0001; CON: 12.662+0.773 [SE=.290], p=.01), whereas mental HRQoL only improved in CON (13.647+1.247 [SE=.336], p<.001). Significant improvements in motor (INT: 1.437+0.203 [SE=.075], p=.009.; CON: 1.437+.210 [SE=.081], p=.012) and processing (INT: 1.111+0.110 [SE=.053], p=.042; CON: 1.111+0.145 [SE=.057], p=.014) performance of ADL have been observed in both groups. CONCLUSIONS: Compared to moderate training, HIIT over three weeks does not show superior effects on HRQoL and ADL measures. However, both HIIT and moderate training seem to have profound clinical impact by improving overall HRQoL and performance of ADL in pwMS.Trial registration NCT03652519
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