INFLUENCE OF HESPERIDIN ON SOME BIOCHEMICAL INDICATORS IN MICE IN SETTING OF EXTRACTING PHYSICAL LOADING

Abstract

A study was carried out on the effect of hesperidin, administered at a dosage of 100 mg / kg, on biochemical parameters in mice in the setting of exhausting physical exertion. The change in biochemical parameters was assessed after the «Treadmill» test, which was carried out during 5 days. After that, blood was tested for further assessment of the following markers of fatigue: lactic (LA), pyruvic acid (PA), and myoglobin. These compounds were determined using a standard set of reagents. It was found that against the background of intragastric administration of the studied flavonoid hesperidin in relation to the negative control group, there was a significant decrease in lactate level by 2.3 times (p <0.05), an increase in pyruvate by 8.8 times, a decrease in the lactate / pyruvate 21.2 times (p <0.05). It should also be noted that the myoglobin level was lower at 2.0 (p <0.05) in comparison with the negative control group. There were no significant differences between the group that received hesperidin during the experiment and the group of mice that received Mexidol in the above parameters (LA, PA, LA / PA, myoglobin). The results of the study obtained allow us to recommend this compound as a corrector of biochemical shifts that can occur during exhausting loads.