Abstract
BACKGROUNDThe effect of hepatitis delta virus (HDV) infection on the clinical course of cirrhosis type B is poorly defined.AIMSTo investigate the impact of HDV status on morbidity and mortality in...
Highlights
The eVect of hepatitis delta virus (HDV) infection on the clinical course of cirrhosis type B is poorly defined
ANTI-HDV/HBeAG STATUS We evaluated 200 white patients with hepatitis B surface antigen (HBsAg) positive compensated cirrhosis who fulfilled the inclusion criteria
Our results indicate that HDV infection modifies to a certain extent the clinical and serological presentation of HBsAg positive cirrhosis
Summary
Sperimentale, Clinica Medica 2a, University of Padova, Italy G Giustina min concentration, -globulin concentration, and HDV status as significant independent prognostic variables. Bispebjerg University Hospital, Copenhagen, Denmark E Christensen tion, and mortality was increased by a factor of 3.2 (1.0 to 10), 2.2 (0.8 to 5.7), and 2.0 (0.7 to 5.7) respectively in anti-HDV positive relative to HDV negative cirrhotic. University of risk for HCC was 13, 4, and 2% for Sassari, Italy G Realdi anti-HDV positive/HBeAg negative, antiHDV negative/HBeAg negative, and anti-. Conclusions—HDV infection increases the risk for HCC threefold and for Correspondence to: Dr G Fattovich, Servizio mortality twofold in patients with cirrhosis type B. There are insuYcient data to clarify whether HDV alters the clinical course of HBV related compensated cirrhosis and increases the risk of hepatocellular carcinoma (HCC). Namely incidence of complications of cirrhosis and incidence of HCC, and mortality were compared in anti-HDV positive and negative patients
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