Abstract
Background. H. pylori infection is one of the most common chronic infectious inflammatory diseases worldwide and is also a risk factor for atherosclerosis. Patients with metabolic syndrome are known to be at increased risk for atherosclerosis. The aim of our study was to assess the effects of H. pylori infection on serum lipids, body mass index (BMI), and metabolic syndrome in old Chinese people. Material and Method. A total of 191 (133 males and 58 females, aged 73.19 ± 11.03 years) people who had gastroscopy examination in our hospital were divided into H. pylori-positive group (n = 80) and H. pylori-negative group (n = 111). H. pylori infection was diagnosed by rapid urease test. Results. Patients with H. pylori infection had higher BMI and fasting glucose levels and incidence of metabolic syndrome (p < 0.01). It was found that BMI (p < 0.01, OR 74.469), H. pylori infection (p < 0.01, OR 5.427), total cholesterol (p < 0.01, OR 15.544), and diabetes mellitus (p < 0.01, OR 23.957) were significantly associated with the risk of metabolic syndrome by binary logistic regression analysis. Conclusions. Patients with H. pylori infection had higher BMI and fasting glucose levels and had incidence of metabolic syndrome.
Highlights
H. pylori, a Gram-negative bacterium that dwells on the gastric epithelium, infects over 50% of the human population, with a high rate in those living in developing countries [1]
This study showed a positive association between H. pylori infection and the prevalence of metabolic syndrome among a group of subjects from middle-aged to elderly Chinese population, which is in agreement with the previous studies [10, 11]
According to the multiple logistic regression analyses performed in this study, H. pylori infection was found to be associated with an increased risk of metabolic syndrome, indicating that H. pylori infection could be used as a risk factor of metabolic syndrome
Summary
H. pylori, a Gram-negative bacterium that dwells on the gastric epithelium, infects over 50% of the human population, with a high rate in those living in developing countries [1]. H. pylori can cause many gastrointestinal diseases, including peptic ulcers, chronic gastritis, and gastric mucosa-associated lymphoid tissue lymphoma (MALToma). It is considered a class I carcinogen that can induce chronic inflammation and gastric cancer [2, 3]. H. pylori may disturb lipid and glucose metabolism in a way that may increase the risk of atherosclerosis [7]. It was found that BMI (p < 0.01, OR 74.469), H. pylori infection (p < 0.01, OR 5.427), total cholesterol (p < 0.01, OR 15.544), and diabetes mellitus (p < 0.01, OR 23.957) were significantly associated with the risk of metabolic syndrome by binary logistic regression analysis. Patients with H. pylori infection had higher BMI and fasting glucose levels and had incidence of metabolic syndrome
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