Abstract
The present study reports in silico investigation of bioactive compounds from marine microalgae capable of escalating copepod fecundity potential through enhanced heat shock protein (HSP-70) production. The structure of ligand (bioactive compounds from microalgae) and hsp-70 obtained from the databases of PubChem and Protein Data Bank (PDB), respectively. Molecular Docking was performed by GOLD software and ligand interaction pathways using web server MANORAA. Fourteen bioactive compounds showed good biding interaction with specific protein HSP-70 and seven of these compounds showed high hydrogen bond interaction with key amino acids (phenylalanine, tyrosine and tryptophan). The highest binding energy of 50.21 is recorded in the bioactive compound, arachidonic acid from the red alga Porphyridium cruentum TYR 167 involved in the biosynthesis pathway of phenylalanine, tyrosine and tryptophan also showed specific target site of tryptophan synthase (4.2.1.20). Results suggest with P. cruentum feed copepod culture could boost their fecundity leading to high density culture.
Highlights
Marine food webs depend on zooplankton especially, copepods to process and repackage energy harnessed by photosynthetic primary producers
The present study reports in silico investigation of bioactive compounds from marine microalgae capable of escalating copepod fecundity potential through enhanced heat shock protein (HSP-70) production
The structure of ligand and hsp-70 obtained from the databases of PubChem and Protein Data Bank (PDB), respectively
Summary
Marine food webs depend on zooplankton especially, copepods to process and repackage energy harnessed by photosynthetic primary producers. Biochemical studies have shown that copepods are rich in proteins, lipids, essential amino acids, and essential fatty acids which can enhance reproduction, augment growth, immune stimulation, and color intensification in prawn and fish larvae (Lavens & Sorgeloos, 1996; Aman & Altaff, 2004). For this reason, copepods are cultivated for use as live feed for newly hatched finfish larvae in marine aquaculture systems. The egg productions of marine copepod may be under favorable or unfavorable environmental conditions. When a copepod embryo undergoes quiescence, it requires a number of stabilizing factors (Nilsson et al, 2014)
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