Influence of growth factors on poultry myogenic satellite cells

Abstract

Skeletal muscle development in avian and mammalian embryos depends on the proliferation, differentiation, and fusion of embryonic myoblasts. During the late fetal period and following birth or hatching, myogenic satellite cells are responsible for this developmental function. Satellite cells, which are found adjacent to existing skeletal muscle fibers fuse with these fibers and their nuclei direct the synthesis of new protein and function in the maturation of muscle. These events are controlled by specific growth factors that are produced locally by satellite cells and other cells in the muscle. Progress in our understanding of the early events in myogenesis has been made possible by the development of satellite cell cultures and media formulations that allow the assessment of the role of growth factors in skeletal muscle growth and development. Because of the key role that satellite cells play in skeletal muscle growth, development, and regeneration, many scientists in both the agricultural and medical communities have focused their research on understanding the physiology of this cell. From an agricultural perspective, a better understanding of the mechanisms regulating satellite cell activity may lead to procedures to increase the deposition and efficiency of lean muscle (meat) accretion and, perhaps, improve the nutrient composition of meat products.