Influence of graviceptor stimulation initiated by off-vertical axis rotation on ventilation.

Abstract

What is the central question of this study? It is known that respiration is affected by graviceptors, but it remains unclear to what extent labyrinthine and non-labyrinthine graviceptors are involved in this process. What is the main finding and its importance? Our results suggest that the modulation of respiration is not a result of a simple reflex arc, but that it involves a higher integration of different types of receptors with variable contributions of either type of graviceptor among subjects. It has been suggested that the otolith system is involved in the physiological response to changes in body orientation with respect to gravity. In studies on animals, an otolith-respiratory reflex has been observed, but data on humans are scarce and inconclusive, mainly because pure otolithic stimulation is difficult to produce in humans. To assess the otolithic-respiratory reflex in humans, we used an off-vertical axis rotation (OVAR) that produces periodic and pure stimulation of graviceptors. The inspiratory flow was measured during earth vertical axis rotation (EVAR, control conditions) and OVAR in 21 subjects. To distinguish the effects of the labyrinthine and non-labyrinthine graviceptors on ventilation, these measurements were repeated with two different static head positions: head turned leftward and rightward in yaw. The velocity of rotation was individually selected to match spontaneous breathing rate (mean 11.4cyclesmin-1 , 0.19Hz). Average ventilatory flow was higher in OVAR than in EVAR, as was tidal volume. In OVAR, the transition between inspiration and expiration occurred mainly in the forward pitch position. The phase of this transition in most subjects was driven mostly by the body position rather than by the head position, suggesting that respiratory modifications during OVAR mainly involved non-labyrinthine receptors. However, the study demonstrated a high intersubject variability both in the ability of OVAR to synchronize breathing and in the influence of labyrinthine stimulation. We conclude that the respiratory response to changes in orientation of the body with respect to the vertical involves labyrinthine and non-labyrinthine stimulation, with the gain of each signal varying individually.