Abstract
The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
