Abstract
The effect of 10% glucose solution and narcosis upon the blood borne cancer cells was studied on Wistar rats, with Walker 256 carcinosarcoma inoculated intravenously.Our experiment reveals obvious differences between the control group and the groups treated with glucose concerning incidence, localization and tumour extension, differences which suggest that there is a risk in using glucose in the intra- and post-surgical resuscitation of patients with cancer.
Highlights
Our experiment reveals obvious differences between the control group and the groups treated with glucose concerning incidence, localization and tumour extension, differences which suggest that there is a risk in using glucose in the intra- and post-surgical resuscitation of patients with cancer
The biochemical investigations have revealed that a certain level of glycolysis characterizes the systems with rapid growth and. at least in tumour tissues, there is a relationship between the intensity of glycolytic activity and the rate of tumour growth (Wenner, 1967; Mustea, 1968)
Considering the important role glucose plays in cell metabolism, we wondered whether the perfusion of 10% glucose solution, given during operation and continued during the post-surgical resuscitation, has any influence upon the blood borne cancer cells and may influence the metastatic process
Summary
Summary.-The effect of 10% glucose solution and narcosis upon the blood borne cancer cells was studied on Wistar rats, with Walker 256 carcinosarcoma inoculated intravenously. Our experiment reveals obvious differences between the control group and the groups treated with glucose concerning incidence, localization and tumour extension, differences which suggest that there is a risk in using glucose in the intra- and post-surgical resuscitation of patients with cancer. IMPROVEMENT in surgical techniques, the discovery of antibiotics and advances in anaesthesia and resuscitation have reduced the rate of post-surgical mortality and brought surgical treatment to the forefront of therapy for some kinds of tumour (Chiricuta et al, 1972). Considering the important role glucose plays in cell metabolism, we wondered whether the perfusion of 10% glucose solution, given during operation and continued during the post-surgical resuscitation, has any influence upon the blood borne cancer cells and may influence the metastatic process.
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