Abstract
ABSTRACT This study evaluated the influence of glucose and stirring in the fermentation process in order to produce anti-Candida metabolites produced by Streptomyces sp. MPO4 isolated from Amazon soil. The anti-Candida metabolites production was registered after 24 h of fermentation in stirred ISP2 medium, having antifungal inhibition halos between 12.3 mm and 25.3 mm, yielding higher production of anti-Candida agents after 96 h. Stirring was a determining factor for the production of anti-Candida secondary metabolites, since the absence of glucose reflected in the late production of the antifungal starting from Streptomyces sp.
Highlights
The bioactive compounds of microbial origin are produced by specific groups of bacteria and eukaryotic microorganisms such as Actinomycetes, Themyxobacteria, Pseudomonas and the Cyanobacteria and most of filamentous fungi.Actinobacteria are Gram-positive filamentous bacteria group with high capacity to produce several secondary metabolites (Jørgensen et al, 2010; KaruppiahActinomycetes may be exist in various habitats such as water, soil and plants, which are estimated for each gram of soil there are about 106 - 109 Colony Forming Units (CFU) by actinomycetes
This study evaluated the influence of the glucose presence and stirring to produce compounds with antiCandida activity produced by Streptomyces sp
EBR-49 UFPEDA isolated from plant roots Conyza bonariensis (L.), it was observed that the largest zones of inhibition were against Bacillus subtilis ATCC 6633 in ISP2 medium, concluding that this is the best medium for the production of bioactive compound for that lineage
Summary
The bioactive compounds of microbial origin are produced by specific groups of bacteria and eukaryotic microorganisms such as Actinomycetes, Themyxobacteria, Pseudomonas and the Cyanobacteria and most of filamentous fungi.Actinobacteria are Gram-positive filamentous bacteria group with high capacity to produce several secondary metabolites (Jørgensen et al, 2010; KaruppiahActinomycetes may be exist in various habitats such as water, soil and plants, which are estimated for each gram of soil there are about 106 - 109 Colony Forming Units (CFU) by actinomycetes. The bioactive compounds of microbial origin are produced by specific groups of bacteria and eukaryotic microorganisms such as Actinomycetes, Themyxobacteria, Pseudomonas and the Cyanobacteria and most of filamentous fungi. Actinobacteria are Gram-positive filamentous bacteria group with high capacity to produce several secondary metabolites Actinomycetes may be exist in various habitats such as water, soil and plants, which are estimated for each gram of soil there are about 106 - 109 Colony Forming Units (CFU) by actinomycetes. Its wide distribution is justified because these bacteria are not very demanding in terms of. M. Araújo the substrate for growth, as they are described autotrophic genres, heterotrophic, chemotrophic or phototrophic (González et al, 2005)
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