Abstract
It’s studied in vitro the intensity of lipid synthesis of various classes (fatty acids, cholesterol, phospholipids and acylglycerols) in homogenates of liver, brain, small intestinal mucosa and adipose tissue after daily single injection of guinea pigs with cholesterol (300 mg/kg body weight) for 30 days. For this purpose, it’s determined the radioactivity of the lipid fractions of the referred above tissue homogenates of guinea pigs that was incubated with [1-14C] palmitic acid. It’s established the inhibitory effect of exogenous cholesterol, under increase its level in the diet of guinea pigs, on the diacylglycerol synthesis and on the free cholesterol in the small intestine mucosa and on the triacylglycerol synthesis in adipose tissue under usage as a precursor – [1-14C] palmitic acid. It’s determined a significant reduction in the intensity of total lipids and individual lipid classes by using as a precursor [1-14C] palmitic acid in in vitro conditions in the brain, liver, small intestinal mucosa and adipose tissue of guinea pigs with hypercholesterolemia when it’s given them fish oil as feed.
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