Abstract
BackgroundLimited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fibrinogen and C-reactive protein (C-RP) on the progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients.MethodsSixty two patients with T2D and PAD (mean age 60.28 ± 27 years and diabetes duration of 8.58 ± 6.17 years) were enrolled in a cohort prospective study of 36 months. Ankle-brachial index (ABI) was measured in all patients at baseline and after 36 months. Multiple linear regression analysis was used to determine the predictivity of variables for fibrinogen, C-RP, plasma lipid fractions, fasting plasma glucose, Body Mass Index (BMI), duration of diabetes status and the age on changes in ABI value.ResultsLinear regression analysis defined F as a predictor for endpoint value of ABI (β = 0.469, p = 0.007). Value of C-RP determinates change of minimal value of ABI (β = 0.449, p = 0.037) and change of mean ABI per year (β = 0.442, p = 0.025).ConclusionOur data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.
Highlights
Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients
Some studies have suggested that the inflammatory biomarkers, C-reactive protein (C-RP) and fibrinogen, play a role in initiation, aggravation of the classical pathways and progression of atherosclerosis in diabetic patients [5,6,7]
The purpose of this study was to determinate the influence of inflammatory biomarkers: fibrinogen and C-RP on progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients as measured with changes in Ankle-brachial index (ABI) values
Summary
Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. Previous studies have found accelerated atherosclerosis and increased risk of vascular disease in diabetic patients [1,2]. Some studies have suggested that the inflammatory biomarkers, C-RP and fibrinogen, play a role in initiation, aggravation of the classical pathways and progression of atherosclerosis in diabetic patients [5,6,7]. These biomarkers are more closely related with. The purpose of this study was to determinate the influence of inflammatory biomarkers: fibrinogen and C-RP on progression of PAD in type 2 diabetic (T2D) patients as measured with changes in ABI values
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