Influence of fatty acids composition in different tissue of mice feeds with fish oils

Flávia Santina Pelissari Quinalha,Omar Cléo Neves Pereira,Luciana Pelissari Manin,Elton Guntendorfer Bonafe,Marina Masetto Antunes,Marília Bellanda Galuch,Jesuí Vergílio Visentainer,Eloize Silva Alves,Guilherme Godoy,Oscar Oliveira Santos,Roberto Barbosa Bazotte

doi:10.33448/rsd-v10i16.23706

Flávia Santina Pelissari Quinalha, Omar Cléo Neves Pereira + Show 9 more

Open Access

https://doi.org/10.33448/rsd-v10i16.23706

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Abstract

Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play an important role in human health. Fish oils enriched with EPA and DHA have commercialized in triacylglycerol (TAG) and ethyl ester forms (EE). In this study, we compared the impact of diets containing fish oil in ethyl ester and triacylglycerol forms as a lipid source in five different tissues as liver, skeleteral muscle, brain, and epididymal white adipose tissue (WAT). The DHA levels were higher in the WAT and skeletal muscle of TAG and EE groups in comparison with the SB group. The body weight and brain, liver, epididymal WAT, and gastrocnemius muscle weights, and serum glucose, TG, cholesterol were not different between the groups. Thus, we conclude that EPA and DHA in the form of EE or TAG influence the fatty acids composition of different tissues.

Highlights

The fatty acids (FA) are distributed in all the tissues of living organisms
We compared the impact of diets containing: a) lard and soybean oil as a lipid source (SB diet), b) lard and fish oil in the form of ethyl ester (EE diet) as a lipid source, c) lard and fish oil in the form of TAG (TAG diet) as a lipid source
The saturated FA (SFA), monounsaturated FA (MUFA), and PUFA are present in all diets

Summary

Introduction

The fatty acids (FA) are distributed in all the tissues of living organisms. They have been received special attention considering that the quantity and quality of FAs consumed in the diet play different roles in physiological processes (Wanten & Calder, 2007). LC-PUFA) and omega-6 long-chain polyunsaturated fatty acids (n-6 LC-PUFA) have increased. It is due their beneficial effects on human health. N-3 LC-PUFA modulates cell membrane permeability and reduces thrombosis, cardiovascular diseases, diabetes, inflammatory diseases, and neurological disorders (Wang et al, 2018). Two important n-3 LC-PUFA are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

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