Abstract
Background To evaluate cardiac autonomic modulation of adolescents with a family history of diabetic parents. Objective This study aims to evaluate the influence of a family history of diabetes on cardiac autonomic modulation. Methods This is an analytical and cross-sectional study on adolescents between 11 and 18 years of age, of both genders, who were divided into group with a family history of diabetes and a control group without a family history of diabetes. The study protocol consisted of the analysis of heart rate variability, blood pressure, anthropometric measurements, and body composition. Also, by using questionnaires, level of physical activity, sexual maturation, and sleep quality were evaluated. Normality of data distribution was tested using the Kolmogorov-Smirnov test. Then, statistical significance was evaluated using the Student's t-test, and the Cohen’s teste was used for calculation of the effect size. The level of significance adopted in the statistical analysis was 5%. Results When the group of individuals with a family history of diabetes was compared with the control group, statistically significant differences were observed in the variables the standard deviation of the NN time series interval (SDNN) (43.9 ± 2.2 vs. 53.5 ± 2.6 ms), the square root of the quadratic differences (RMSSD) (41.9 ± 3.3 vs. 52.4 ± 3.2 ms), standard deviation of beat-to-beat instantaneous variability (SD1) (29.7 ± 2.3 vs. 37.1 ± 2.3 ms), long-term standard deviation of continuous RR intervals (SD2) (. 54.1 ± 2.6 vs. 66.66 ± 3.5 ms), and in low frequency (LF) (496.0 ± 49.5 vs. 728 ± 71.6 ms2) and high frequency (HF) (1050.0 ± 120.4 vs. 737.4 ± 98.5 ms2) in the frequency domain. Conclusions Global autonomic modulation is decreased in adolescents with a family history of diabetes. We also observed a decrease in vagal activity in this group. So, sympathetic autonomic modulation is predominant in this population. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)
Highlights
Among the most common non-communicable chronic diseases worldwide, diabetes mellitus (DM) stands out because it affects more than 340 million people in the world.[1]
The main risk factors for the pathogenesis of DM are related to family history and lifestyle, such as impaired fasting blood glucose, reduced glucose tolerance, gestational diabetes, birth weight greater than 4 kg, sedentary lifestyle, dyslipidemia
To participate in the study, individuals should be present at all stages of data collection, which consisted of: (1) public call for the study and explanation about the project; (2) signature of the informed consent form by the parent or guardian of the child or adolescent, and signature of the informed consent form by the child or adolescent participating in the project; (3) assessment of anthropometric measurements and sexual maturation, administration of sleep quality questionnaires and physical activity level, and collection of capillary blood glucose and hemodynamic data
Summary
Among the most common non-communicable chronic diseases worldwide, diabetes mellitus (DM) stands out because it affects more than 340 million people in the world.[1]. To evaluate cardiac autonomic modulation of adolescents with a family history of diabetic parents. Objective: This study aims to evaluate the influence of a family history of diabetes on cardiac autonomic modulation. Results: When the group of individuals with a family history of diabetes was compared with the control group, statistically significant differences were observed in the variables the standard deviation of the NN time series interval (SDNN) (43.9 ± 2.2 vs 53.5 ± 2.6 ms), the square root of the quadratic differences (RMSSD) (41.9 ± 3.3 vs 52.4 ± 3.2 ms), standard deviation of beat-to-beat instantaneous variability (SD1) (29.7 ± 2.3 vs 37.1 ± 2.3 ms), longterm standard deviation of continuous RR intervals (SD2) Conclusions: Global autonomic modulation is decreased in adolescents with a family history of diabetes. (Int J Cardiovasc Sci. 2020; 33(4):360-367) Keywords: Diabetes/heredity; Diabetes/Epidemiology; Adolescent; Body Weight; Body Mass Index, cardiac Autonomic System Sympathetic autonomic modulation is predominant in this population. (Int J Cardiovasc Sci. 2020; 33(4):360-367) Keywords: Diabetes/heredity; Diabetes/Epidemiology; Adolescent; Body Weight; Body Mass Index, cardiac Autonomic System
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