Influence of Eyes Movement on Lens Dose during MR-Guided Radiotherapy for Brain Tumor

Abstract

Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs at risk such as lens. The magnitude of eyes movement and its influence on lens dose is unclear. The lens dose is relevant for cataract formation. This study aims to evaluate the movement-range of lens and its influence on dose distribution during MR-guided radiotherapy for brain cancer patients. Fifty patients with brain cancer who were treated with MR-guided radiotherapy on 1.5 T MR-Linac were included in this study. All patients underwent a pre-treatment MRI and post-treatment MRI for each fraction. The eyes and lens were delineated on each MR image by a radiation oncologist. The reference treatment plans based original CT were recalculated on each MRI by "adapt to position" workflow. Then, we created planning risk volume (PRV) for lens by adding population margin and reoptimized the reference plans to evaluate the dose changes for lens. Inter-fraction and intrafraction variability for eyes and lens were evaluated with the Dice similarity coefficient (DSC), the Hausdorff distance (HD) and mean distance to agreement (MDA). Differences in daily dose (Dmax and Dmean) for eyes and lens were assessed. A total of 300 MR images were analyzed in this study. The eyes motion was observed (minimum DSC: 0.57; maximum HD: 10.53; maximum MDA: 3.13). And the obvious lens motion also was found (minimum DSC: 0.01; maximum HD: 10.78; maximum MDA: 5.68). The maximum dose changes for eyes were up to 34.1% and the mean dose changes were up to 18.1%. The maximum dose changes for lens were up to 97.9% and the mean dose changes for eyes were up to 89%. When the reoptimized plans were generated by PRV lens, the dose changes were decreased nearly to 0. Eyes movements in all radiotherapy fractions result in higher lens doses and potentially increase cataract formation rate. Adding margin expansions in treatment planning, to account for eyes motion, is the feasible approach to limit lens dose.