Abstract
1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3–2.5 mM Ca 2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30–300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium.
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