Abstract
Modification of the response of the adrenal gland to ACTH was observed in hypophysectomized rats exposed to cold with or without ascorbic acid treatment. Changes in weight and metabolic activity of the gland were used to measure the adrenal response. All comparisons were made between the left and the right adrenal of each animal before and after treatment. The results obtained show that cold stress increases the response of the adrenal to a standard dose of two units of ACTH; they also indicate that ascorbic acid administration increases so much the responsiveness of the adrenal gland to ACTH at room temperature that such a response is not enhanced by exposure to cold.
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