Abstract
Summary Milanova, A. , R. R. Santos, L. Lashev, V. Koinarski & J. Fink - Gremmels , 2015. Influence of experimentally induced Eimeria tenella inf ection on gene expression of some host r e sponse factors in chickens . Bulg. J. Vet. Med. (online first). Coccidiosis in poultry is associated with significant damage of intestinal integrity and i n volvement of innate immunity. Therefore, the aim of this stu dy was to evaluate genes, e n coding the innate immune response in broiler chickens, such as LEAP, IFN - , iNOS and IL - 8 together with PepT1 and ABCG2 transporters after E. tenella challenge. E. tenella infe c tion provoked up - regulation of iNOS mRNA in the duo denum and of IFN - and iNOS mRNAs in the caecum and the liver. IL - 8 mRNA expression in the liver was increased and LEAP mRNA was decreased. On the sixth day after the challenge with E. tenella, ABCG2 mRNA was increased in the duodenum and the liver while PepT1 mRNA was up regulated in the duodenum. The expression of these genes in the caecum was not changed. In concl u sion, several factors of the host immune response can be affected by E . tenella infection not only in the target caecal tissue but also in the liver and to a lesser degree in the duodenum. The caecal co c cidiosis can provoke significant changes in the integrity of the intestines by affecting of ABCG2 and PepT1 mRNA levels.
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