Abstract
THE administration of ethylenediamine-tetra-acetic acid (versene, sequestrene) causes increased urinary excretion of calcium, iron, lead and other metallic ions1. We became interested in this chelating agent as a possible means for reducing zinc stores and thus hastening the onset of deficiency in rats maintained on a diet low in zinc. Information on the effect of ethylenediamine-tetra-acetic acid on zinc metabolism was also required in planning an investigation of the excretion of recently absorbed zinc-65. Stability constants indicate2 that zinc forms one of the most stable complexes with ethylenediamine-tetra-acetic acid, but we are not aware of any previous experiments to test its action on body stores of zinc, apart from a brief reference to unpublished work by Mager3.
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