Abstract
BackgroundPotassium bromate (KBrO3) has been used widely for water disinfection, hair coloring, oxidizing agent in food, food additive in bread making process as maturing agent, and as dough conditioner for flour.PurposeThis study was carried out to investigate the effects of two doses (150 and 300 mg/kg) of ethanolic extract of strawberry leaves on antioxidant capacity of liver, kidney and testis, thyroid hormones, and kidney function in rats treated with potassium bromate as toxic and free radical producer compound.Study designForty-eight male rats were divided: group 1 served as control, group 2 treated with oral dose of strawberry leaves extract (150 mg/kg), group 3 treated with oral dose of strawberry leaves extract (300 mg/kg), group 4 treated with oral dose of potassium bromate (20 mg/kg), group 5 treated with strawberry leaves extract (150 mg/kg) and potassium bromate (20 mg/kg), and group 6 treated with strawberry leaves extract (300 mg/kg) and potassium bromate (20 mg/kg) for 4 weeks.MethodsDetermination of thiobarbituric acid reactive substance (TBARS), glutathione (GSH), and superoxide dismutase (SOD) in liver, kidney, and testis tissues. Measurements of serum total protein, albumin, urea, creatinine, free triiodothyronine (FT3), free thyroxine (FT4), and insulin.ResultsAdministration of potassium bromate (KBrO3) induced significant increase in TBARS; decrease in GSH and SOD in liver, kidney, and testis tissues; non-significant decrease in total protein and albumin; significant increase in serum urea, creatinine, and FT3; and significant decrease in FT4 and insulin. Administration of strawberry leaves extract showed significant improvement in some studied parameters.ConclusionIn conclusion, the protective effect of strawberry leaves extract may be attributed to its antioxidant property.
Highlights
Potassium bromate (KBrO3) has been used widely for water disinfection, hair coloring, oxidizing agent in food, food additive in bread making process as maturing agent, and as dough conditioner for flour.Purpose: This study was carried out to investigate the effects of two doses (150 and 300 mg/kg) of ethanolic extract of strawberry leaves on antioxidant capacity of liver, kidney and testis, thyroid hormones, and kidney function in rats treated with potassium bromate as toxic and free radical producer compound
In conclusion, the protective effect of strawberry leaves extract may be attributed to its antioxidant property
The metabolism of potassium bromate is stable in the body and small amounts can be reduced to bromide by glutathione in the liver and cause the decrease in GSH level in rats administered potassium bromate (Kutom, Bazilski, Magana, & Deunea, 1990)
Summary
Potassium bromate (KBrO3) has been used widely for water disinfection, hair coloring, oxidizing agent in food, food additive in bread making process as maturing agent, and as dough conditioner for flour.Purpose: This study was carried out to investigate the effects of two doses (150 and 300 mg/kg) of ethanolic extract of strawberry leaves on antioxidant capacity of liver, kidney and testis, thyroid hormones, and kidney function in rats treated with potassium bromate as toxic and free radical producer compound. Potassium bromate (KBrO3) has been used widely for water disinfection, hair coloring, oxidizing agent in food, food additive in bread making process as maturing agent, and as dough conditioner for flour. Potassium bromate (KBrO3) has been used widely for water disinfection, hair coloring, oxidizing agent in food, food additive in bread making process as maturing agent (Kurokawa, Maekawa, Takahashi, & Hayashi, 1990), and Mohamed and Ashour The Journal of Basic and Applied Zoology (2019) 80:19. Bromate was found to be genotoxic and carcinogenic (Sai, Vchiyama, Ohno, Hasegawa, & Kurokawa, 1992) while potassium bromate has been evaluated for acceptable level in flour to be consumed by man (FAO/WHO, 1992) It is used in treating barley in beer making and for improvement of the quality of fish paste products in Japan. There is a relation in the effect of T3 and insulin, determining lipid and glucose metabolic pathways (Lambadiari et al, 2011)
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