Influence of ethanol on the production of allantoin by the perfused rat liver.

Abstract

Ingestion of alcohol is traditionally considered a predisposing or precipitating factor in the gouty attack. Studies performed in man by Lieber et al. (1962) have shown that the administration of ethanol provokes an increase in the serum concentration of uric acid, which was attributed to a decrease in its renal excretion. More recently, ethanol infusion has been shown to enhance the production of uric acid by the liver, as measured from arteriovenous concentration differences during hepatic catheterisation in human volunteers (Grunst et al., 1973).KeywordsUric AcidAdenine NucleotideAdenosine DeaminasePerfuse LiverPerfusion MediumThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.