Abstract
Vinca rosea (Catharanthus roseus L.) is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. The objective of the study is to evaluate the diabetic wound healing activity of Vinca rosea using the excision wound model in a streptozotocin induced diabetic rats. The animals were weight matched and placed into five groups (n=6 per group). Animals in groups 1 and 2 were normal control (Vaseline) and normal experimental (extract treated) respectively; those in groups 3 and 4 were the diabetic control and diabetic experimental batches. Diabetic animals in a reference group 5 were treated with topical mupirocin ointment. All animals were experimentally wounded on the posterior surface. The ethanol extract of Vinca rosea (100 mg kg-1 body weight) was applied to animals of group 2 and 4 for ten days. Wounds were measured on days 1, 5 and 11. The granulation tissue formed on the wound was excised on the 11th day and used for the histology and biochemical work up. The wound size in animals of the Vinca rosea treated group were significantly reduced (P
Highlights
Natural products are a source of synthetic and traditional herbal medicine and are still the primary health care system[1]
There is no previous report on diabetic wound healing activities of Catharathus roseus in literature to the best of our knowledge and in this paper, we report for the first time, the efficacy of Vinca rosea leaf extract in the treatment and management of diabetic wounds
By day 11 wounds in diabetic animals treated with the experimental extract had closed by 44.4% as compared with wounds treated with the standard formulation of mupirocin. (P
Summary
Natural products are a source of synthetic and traditional herbal medicine and are still the primary health care system[1]. Normal wound healing response begins the moment the tissue is injured. The healing cascade begins immediately following injury when the platelets come into contact with exposed collagen. As platelet aggregation proceeds, clotting factors are released resulting in the deposition of a fibrin clot at the site of injury. The inflammatory cells arrive along with the platelets at the site of injury and they provide key signals are known as cytokines or growth factors[3]. The fibroblast is the connective tissue cell responsible for collagen deposition that is needed to repair the tissue injury. In normal tissues collagen provides strength, integrity and structure. When tissues are disrupted following injury, collagen is needed to repair the defect and restore anatomic structure and function
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