Abstract
To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F2α in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up.
Highlights
Estrogen-related receptor γ (ESRRG) is a member of the orphan nuclear hormone receptor family of steroid hormone receptors, which function as constitutive activators of transcription[1] and play various roles in regulating homeostatic and metabolic processes[2, 3]
The observed and expected frequencies of the ESRRG rs1890552 A > G polymorphism were in Hardy-Weinberg equilibrium (HWE) in the entire population and in the normal fasting glucose (NFG) and impaired fasting glucose (IFG) groups
Subjects in the IFG group with a G allele presented a more pronounced glucose reduction. These results suggest a role of the ESRRG rs1890552 A > G polymorphism in modulating interindividual differences in arterial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after 3.5 years of follow-up
Summary
Estrogen-related receptor γ (ESRRG) is a member of the orphan nuclear hormone receptor family of steroid hormone receptors, which function as constitutive activators of transcription[1] and play various roles in regulating homeostatic and metabolic processes[2, 3]. A recent cross-sectional study showed that the ESRRG rs1890552 A > G SNP was a novel candidate variant for impaired fasting glucose (IFG) and T2D, this SNP was not equivalent to the SNPs found in the GWAS4. According to the 2014 Korean National Health and Nutrition Examination Survey (KNHANES VI-2), carbohydrate-derived calories account for 63.8% of the total caloric intake of middle-aged Korean adults, and cooked refined rice is the main source of carbohydrates Due to this high carbohydrate intake, the replacement of refined rice with whole grains and legumes has been suggested to reduce T2D risk factors[15]. We investigated the influence of the ESRRG rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness in response to dietary advice in subjects with IFG over a 3.5-year period
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